What Medicines Interact With Grapefruit

What Medicines Interact With Grapefruit?

May 5, 2023 By tabletmedicine 0

You know we have always heard how healthy and nutritious eating fruits is. And if you are one of those diet freaks who love eating boiled vegetables and fruits all day long I guess it’s time for you to look at your plate considerably. Although the majority of fruits don’t have significant adverse effects however grapefruit is an exception.

There are lots of medicines that interact badly with grapefruit. And the most popular interaction is between Erectile Dysfunction and grapefruits. That means if you consume grapefruit with those certain medicines you might get in trouble with your health. 

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So check out the whole article before you think of consuming grapefruit again. This way will save you from mishaps of grapefruit interactions. Find out if grapefruit is good for you or not.

What Is Grapefruit? 

It’s a subtropical fruit believed to be originated from Barbados. It’s a refreshing citrus fruit tasting a little bit tangy, sour, and buttery. Grapefruit can enhance your skin, decrease cholesterol, increase your immune system, and help you lose weight. However, grapefruit can also interact with some medications, so if you are taking any prescription medications, talk to your doctor before eating it. 

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Why Is Grapefruit Dangerous?

Although grapefruit is delicious and nutritious and has a number of health benefits. However, it can be dangerous for some individuals with certain health conditions or who take certain medications. Here are some reasons why grapefruit drug interaction can be harmful to you.

  • The potency of several medications can be increased by grapefruit interaction. Blood loss, renal damage, an irregular heartbeat, and even death are all possible significant adverse effects of this.
  • Grapefruit may damage the enamel of your teeth and lead to cavities. The high citric acid content in grapefruits can weaken and destroy the enamel of your teeth, increasing the risk of decay.
  • A few people may get gastrointestinal issues after eating grapefruit. Grapefruit’s citric acid can aggravate the discomfort, nausea, and bloating associated with gastritis by irritating the lining of your stomach.
  • For certain individuals, grapefruit can raise their risk of heart disease. The risk of heart attack and stroke may rise if you consume too much grapefruit, which may also elevate blood pressure and cholesterol levels. The grapefruit’s potential interaction with the enzymes that control blood vessel activity  may be the cause of this.

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Which Medications Should Not Be Taken With Grapefruit? 

Now that we have seen the conditions that may potentially worsen your health if grapefruit juice is consumed. But now the question the what drugs interact with grapefruit or its juice. Let’s take a look at the grapefruit and medications that interact poorly.

1. Calcium Antagonists 

Calcium channel blockers may be necessary if you have excessive blood pressure or coronary heart disease. These medicines ease the artery muscles and reduce blood pressure.

Consuming grapefruit juice, however, should be done with caution since it may interact with some calcium channel blockers and cause an increase in the quantity of medicine in your blood. This can cause unwanted side effects and health risks. That’s Why grapefruit and blood pressure is a big no-no.

Some drugs and grapefruit may interact with each other as listed below. If you are consuming any one of them avoid grapefruit consumption. 

  • Lacidipine 
  • Nicardipine 
  • Nimodipine 
  • Verapamil 
  • Felodipine 
  • Amlodipine 

However, Diltiazem named medication doesn’t cause any harm even if you consume it with grapefruit juice.

2. ED Drugs

Some people believe that grapefruit benefits sexually by increasing libido, blood flow, and stamina. But…Grapefruit juice for erectile dysfunction is again a big no. Because some drugs prescribed to treat Erectile Dysfunction, such as sildenafil and tadalafil i.e, Cialis, may interact negatively with grapefruit or grapefruit juice.

Chemicals present in grapefruit may influence how certain drugs are processed by hepatic enzymes. As a result, grapefruit juice and erections have inverse results.

Aside from priapism other side effects of ED medications like Vidalista 80 mg or Kamagra Oral Jelly include flushing, gastroenteritis, stuffy nose, altered vision, and headache. These negative effects may be made worse by grapefruit. All in all grapefruit for men is a bit risky. 

3. Platelet Aggregation Inhibitors

Blood-thinning medications or antiplatelets are used to stop clots or blockages that can result in heart episodes. They function by stopping blood cells called platelets from clinging jointly. But some blood-thinning medications can clash with grapefruit juice and alter how well they operate. 

For example, grapefruit juice can reduce the potency of clopidogrel and raise the chance of bleeding from ticagrelor. If you are incorporating these medications, you should steer clear of this tangy fruit. However, the fruit does not impact dipyridamole or low-dose aspirin, so you can drink it if you take these medications.

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4. Statins

If you are suffering from too much LDL(bad cholesterol), you may need to consume statins. These medications help to decrease cholesterol and lessen the risk of cardiovascular disease. But some statins can interfere with grapefruit or grapefruit juice and induce unwanted side effects. 

For instance, you should stay away from these citrus balls if you take simvastatin as it can boost the amount of the drug in your system and make side effects more likely. You should also limit your intake of grapefruit juice if you take atorvastatin.

It can consume without any issues when taking other types of statins, though. 

5. Coagulation Inhibitors

Anticoagulants are medications that prevent the formation of blood clots. To diminish the chance of major issues including heart episodes, these are administered to individuals who have a high risk of blood clots. But if you take warfarin, you should avoid grapefruit juice. It can make warfarin more powerful and increase your bleeding tendency. This can be dangerous and cause complications.

Meanwhile, rivaroxaban, apixaban, dabigatran, and edoxaban are safe to take with grapefruit. However, consult your physician to get detailed info.

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6. Cytotoxic Medicines

Drugs known as cytotoxic agents destroy or harm cancer cells. They may also be referred to as antineoplastic drugs, or chemotherapeutic agents. Cytotoxic medications come in a wide variety of forms, each with a distinct mechanism of action and intended applications.

They act very adversely when grapefruit is consume simultaneously. So avoid the fruit at every cost if you are taking cytotoxic medicines.

7. Immunosuppressant 

These classes of medicines are prescribed when the immune system of the body is overactive. When the immunity cells begin to kill or attack the healthy cells confusing them with foreign materials. Mainly immunosuppressants are given in two conditions i.e, Organ transplant and autoimmune diseases like rheumatoid arthritis, lupus, and psoriasis. 

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8. Entocort 

A medication called budesonide, which includes a corticosteroid, is sold under the trade name Entocort. It is employed to treat Crohn’s disease, an illness that causes digestive system inflammation.

Entocort and grapefruit can interact and result in severe negative side effects. The liver enzymes’ ability to break down Entocort can influence by grapefruit. This might result in greater blood Entocort levels and raise the risk of adverse effects or overdose.

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